Read Successful Drug Discovery, Volume 1 Books PDF

Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, Christian Klein, Wayne E. Childers

Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, Christian Klein, Wayne E. Childers With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference.
Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug’s discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today?s top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find.
The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by IUPAC, János Fischer, C. Robin Ganellin

Read Successful Drug Discovery, Volume 1 Books PDF by IUPAC, János Fischer, C. Robin Ganellin The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.
Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them.
The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by Mukund S. Chorghade

Read Successful Drug Discovery, Volume 1 Books PDF by Mukund S. Chorghade This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners.
  • Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil)
  • Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson’s disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer
  • Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics

The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, C. Robin Ganellin

Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, C. Robin Ganellin Born out of a project of the IUPAC’s committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by David C Blakemore, Paul M Doyle, Yvette M Fobian

Read Successful Drug Discovery, Volume 1 Books PDF by David C Blakemore, Paul M Doyle, Yvette M Fobian

Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by M.M. Iwu, J. Wootton

Read Successful Drug Discovery, Volume 1 Books PDF by M.M. Iwu, J. Wootton The emergence of new infectious, chronic and drug resistant diseases have prompted scientists to look towards medicinal plants as agents for treatment and prevention. This book provides an interphase between ethnomedical and ethnobotanical approaches to new drug discovery and advances in biotechnology and molecular science that has made it increasingly feasible to transform traditional medicines into modern drugs. These novel approaches also raise new issues and the volume explores economic, ethical and policy considerations of drug development based on indigenous knowledge or traditional medicine.


This work also features standardization and development of phytomedicines for major therapeutic indications, including emerging infectious diseases affecting developing and developed countries.


The publication provides state-of-the-art information on the most innovative science, the research, the industry, the market, and the future of ethnomedicine and drug discovery.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by

Read Successful Drug Discovery, Volume 1 Books PDF by

Advances in Heterocyclic Chemistry, Volume 124, is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Updates in this new volume include sections on the Organometallic Complexes of Azines, The Literature of Heterocyclic Chemistry, Part XV, Heterocycles Incorporating a Pentacoordinated, Hypervalent Phosphorus Atom, and Tautomerism and the Structure of Azoles: NMR Spectroscopy, amongst other related topics. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • Considered the definitive serial in the field of heterocyclic chemistry
  • Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists
  • Provides the latest comprehensive reviews written by established authorities in the field
  • Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, C. Robin Ganellin, David P. Rotella

Read Successful Drug Discovery, Volume 1 Books PDF by János Fischer, C. Robin Ganellin, David P. Rotella Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs.
The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and — together with the previous volumes — constitutes the first systematic approach to drug analogue development.

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by Atta-ur- Rahman, M. Iqbal Choudhary

Read Successful Drug Discovery, Volume 1 Books PDF by Atta-ur- Rahman, M. Iqbal Choudhary “Frontiers in Anti-Cancer Drug Discovery” is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug di

Read More


Read Successful Drug Discovery, Volume 1 Books PDF by Benjamin Blass

Read Successful Drug Discovery, Volume 1 Books PDF by Benjamin Blass

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics.

The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property.”

  • Provides a clear explanation of how the pharmaceutical industry works
  • Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry
  • Explains the transition process from academia or other industries

Read More


Successful Drug Discovery
Language: en
Pages: 364

Successful Drug Discovery

Authors: János Fischer, Christian Klein, Wayne E. Childers
Categories: Medical
Type: BOOK - Published: 2018-04-09 - Publisher: John Wiley & Sons
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary
Synthetic Methods in Drug Discovery
Language: en
Pages: 455

Synthetic Methods in Drug Discovery

Authors: David C Blakemore, Paul M Doyle, Yvette M Fobian
Categories: Science
Type: BOOK - Published: 2016-07-15 - Publisher: Royal Society of Chemistry
Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of
Fragment-based Approaches in Drug Discovery
Language: en
Pages: 391

Fragment-based Approaches in Drug Discovery

Authors: Wolfgang Jahnke, Daniel A. Erlanson
Categories: Science
Type: BOOK - Published: 2006-12-13 - Publisher: John Wiley & Sons
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on
Basic Principles of Drug Discovery and Development
Language: en
Pages: 580

Basic Principles of Drug Discovery and Development

Authors: Benjamin Blass
Categories: Medical
Type: BOOK - Published: 2015-04-24 - Publisher: Elsevier
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in
Pharmacology in Drug Discovery and Development
Language: en
Pages: 350

Pharmacology in Drug Discovery and Development

Authors: Terry Kenakin
Categories: Medical
Type: BOOK - Published: 2016-10-21 - Publisher: Academic Press
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book