Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Sanjay J. Mathew, Carlos A. Zarate, Jr.

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Sanjay J. Mathew, Carlos A. Zarate, Jr.

This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants.

Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose.

This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Dr. Stephen J. Hyde

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Dr. Stephen J. Hyde

Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing.

This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and costeffective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home.

Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by John F. Greden, Michelle B. Riba, Melvin G. McInnis

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by John F. Greden, Michelle B. Riba, Melvin G. McInnis

As many as 35-40% of patients afflicted with Major Depressive Disorder (MDD) are treatment resistant, a situation that places a massive emotional and financial burden on society and challenges the mental health profession to develop new treatment paradigms and practices. Even the most astute clinicians can be frustrated when treatment options fail to be effective or work for only a brief time, leaving them to wonder what course to pursue next. Treatment Resistant Depression: A Roadmap for Effective Care gives clinicians and their patients what they need most desperately: a sequence of steps that reflect state-of-the-art diagnostic procedures and integrates all evidence-based treatment modalities — in short, a roadmap to wellness and recovery.

Based primarily on the experiences of the authors, all of whom are leading researchers and/or clinicians in Treatment Resistant Depression and affiliated with the University of Michigan Comprehensive Depression Center, the book also draws upon the clinical research advances and treatment innovations of programs around the world. Although the book’s step-by-step organization is clear and easy to follow, its coverage, scope, and level of sophistication are anything but simplified. This book * Is comprehensive, addressing treatment options, including psychopharmacotherapy, psychotherapy, neuromodulation (ECT, transcranial magnetic stimulation, deep brain stimulation, vagus nerve stimulation), exercise, nutrition, self-management approaches to enhance adherence, behavioral sleep programs, and others* Addresses treatment resistant depression across the lifespan, reflecting the diverse demographics of depression, which knows no age, gender, or socioeconomic status* Emphasizes the authors’ commitment to early intervention and provides techniques for identifying young people who are at risk for developing depression or already expressing symptoms of the disease* Recognizes the chronicity of depression, rather than focusing on only the acute stage, and in this way allows for more effective treatment over the patient’s lifetime* Introduces self-management as playing a critical role in the patient’s prognosis, engagement, adherence to clinical steps that help maintain recovery, and self-esteem* Promotes the development of new, personalized, and predictive biomarkers to target treatment more effectively.

Designed to be useful across disciplines and treatment modalities, the book includes a multitude of tables, graphs, and learning aids that will benefit students, instructors, and clinicians. At the same time, the book promises to be a valuable resource for patients and their families, since Treatment Resistant Depression is both difficult to live with and little understood. No other book offers so much practical guidance, sound research and hope.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by David T. Yew

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by David T. Yew

Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamine’s effects on various systems of the body. Ketamine: Use and Abuse reviews the acute and chronic effects of ketamine on both adult and developing animals and humans.

Providing an exhaustive review of the literature, the book is supplemented by the introduction of new data and research. Topics include:

  • The pharmacological properties of ketamine
  • The impact of ketamine on various organ systems, including the central nervous system and the gastrointestinal, respiratory, adrenal, and renal systems
  • Developmental neurotoxicity in the developing brain
  • Postmortem toxicology
  • The epidemiology of misuse and patterns of acute and chronic toxicity
  • The psychosocial aspects of ketamine addiction
  • Clinical applications at acceptable doses, including possible contribution to the treatment of depression

The contributions in this book represent an initiative to investigate the different facets of ketamine beyond the known psychosocial factors related to addiction and its traditional use as an anesthetic agent. The broad-based coverage is designed to promote heightened attention on the subject and encourage further research into beneficial clinical uses.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Karl L. R. Jansen


Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Kenneth Ring, Stanislav Grof, Ralph Metzner, Stanley Krippner, Eli Kolp, Harris Friedman, Evgeny Krupitsky, Karl Jansen, Mark Sylvester, M. Scott Young, Anna Kolp, Wesley Ryan, Cole Marta, Ralph Koek, Stephen Hyde, Steven Levine, Terrence Early, Jeffrey Becker

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Kenneth Ring, Stanislav Grof, Ralph Metzner, Stanley Krippner, Eli Kolp, Harris Friedman, Evgeny Krupitsky, Karl Jansen, Mark Sylvester, M. Scott Young, Anna Kolp, Wesley Ryan, Cole Marta, Ralph Koek, Stephen Hyde, Steven Levine, Terrence Early, Jeffrey Becker The Ketamine Papers opens the door to a broad understanding of this medicine’s growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer new hope for patients and clinicians alike. With multiple routes of administration and practices ranging from anesthesia to psychotherapy, ketamine medicine is a diverse and rapidly growing field. The Ketamine Papers clarifies the issues and is an inspiring introduction to this powerful tool for healing and transformation—from its early use in the 1960s to its emerging role in the treatment of depression, suicidality and other conditions. This comprehensive volume is the ideal introduction for patients and clinicians alike, and for anyone interested in the therapeutic and transformative healing power of this revolutionary medicine.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Basant Pradhan

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Basant Pradhan

This book attempts to bridge the considerable gaps that exist between spiritual philosophies and evidence-based medicine and between the psychotherapeutic models of the East and the West. Based on the insights of both the ancient wisdom and modern medicine, this book presents Yogic science not just as a set of physical exercises or religious rituals but as theories about the mind that have bio-psycho-social implications in relation to health and illness.

Drawing on his years of monastic training and his extensive experiential, clinical and research knowledge on the utility of Yoga meditation in standardized and evidence-based medicine protocols, the author describes symptom-specific clinical applications of Yogic/meditative techniques using standardized protocols for the various psychiatric and psychosomatic conditions. In addition, he explains the value of these techniques in reducing stress and improving quality of life in healthy populations. Dr. Pradhan names the proposed integrative model of psychotherapy Yoga and Mindfulness Based Cognitive Therapy (Y-MBCT). Unlike other models, Y-MBCT uses Yoga in its entirety (all eight limbs, including meditation) rather than piecemeal. The standardized and evidence-based format of Yoga meditation described in this book will help all aspiring Yoga practitioners and will hopefully also provide the impetus for multicenter research studies on the value of this ancient wisdom.

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Irving Reti

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Irving Reti

Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise
particularly in the last two decades.

Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brain stimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activitydependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation.

Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians.

KEY POINTS
• Includes introductory chapters on relevant neuroanatomy
• Covers both invasive and noninvasive brain stimulation techniques
• Explains basic mechanisms and therapeutic applications
• Written by an international team of leaders in the field
• Illustrated in full color

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Francisco López-Muñoz, Venkataramanujam Srinivasan, Domenico de Berardis, Cecilio Álamo, Takahiro A. Kato

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Francisco López-Muñoz, Venkataramanujam Srinivasan, Domenico de Berardis, Cecilio Álamo, Takahiro A. Kato This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .

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Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Kathleen Benton

Read Ketamine For Treatment-Resistant Depression: The First Decade Of Progress Books PDF by Kathleen Benton

With a focus on end-of-life discussion in aging and chronically ill populations, this book offers insight into the skill of communicating in complex and emotionally charged discussions. This text is written for all clinicians and professionals in the fields of healthcare and public health who are faced with questions of ethical deliberation when a patient’s illness turns from chronic to terminal. This skill is required to manage care well in an age of advanced technology, and numerous autonomous choices. With a palliative care and ethics focus, the manuscript provides case studies illustrating issues which occur in the acuity and chronicity of end of life. Clear tools for clinicians, such as scripting and “the advance care planning video library” are included. The book focuses on the unique concept of outpatient ethics, including readmission prevention and shortened length of stay through good communication for clinicians who will be required to conduct this discussion with patients. The ethical undertone in this text provides a perfect opening for application in healthcare ethics classes, both in fields of public health and healthcare. Medical scholars and physicians, nurse practitioners and physician’s assistants, as well as social workers, both in practice and training, will benefit from this text.

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Ketamine for Treatment-Resistant Depression
Language: en
Pages: 155

Ketamine for Treatment-Resistant Depression

Authors: Sanjay J. Mathew, Carlos A. Zarate, Jr.
Categories: Medical
Type: BOOK - Published: 2016-12-30 - Publisher: Springer
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering
Ketamine
Language: en
Pages: 355

Ketamine

Authors: Karl Jansen
Categories: Drug abuse
Type: BOOK - Published: 2001-01-01 - Publisher:
Books about Ketamine
The Ketamine Papers
Language: en
Pages: 448

The Ketamine Papers

Authors: Kenneth Ring, Stanislav Grof, Ralph Metzner, Stanley Krippner, Eli Kolp, Harris Friedman, Evgeny Krupitsky, Karl Jansen, Mark Sylvester, M. Scott Young, Anna Kolp, Wesley Ryan, Cole Marta, Ralph Koek, Stephen Hyde, Steven Levine, Terrence Early, Jeffrey Becker
Categories: Drug abuse
Type: BOOK - Published: 2016-11-15 - Publisher:
The Ketamine Papers opens the door to a broad understanding of this medicine's growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer
Diseases of the Nervous System
Language: en
Pages: 520

Diseases of the Nervous System

Authors: Harald Sontheimer
Categories: Medical
Type: BOOK - Published: 2015-03-06 - Publisher: Academic Press
The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of
Mad in America
Language: en
Pages: 368

Mad in America

Authors: Robert Whitaker
Categories: Psychology
Type: BOOK - Published: 2001-12-14 - Publisher: Basic Books
Schizophrenics in the United States currently fare worse than patients in the world's poorest countries. In Mad in America, medical journalist Robert Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their